G4793
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G4793
Sigma
Gentamicin sulfate salt
Biotechnology Performance Certified, cell culture tested
| CAS Number: | 1405-41-0 |
| EC Number: | 215-778-9 |
| MDL number: | MFCD00270181 |
Description
| Biochem/physiol Actions | Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3 Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria |
| Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma. |
Properties
| grade | Biotechnology Performance Certified |
| total impurities | Endotoxin, tested |
| suitability | cell culture tested |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| WGK Germany | 2 |
| RTECS | LY2625000 |
References
| Cited Reference | 1. Korzybski, T., et al. Antibiotics: origin, nature, and properties Washington, DC , (1977), 712-723 |
| 2. Lorian, V. (ed.) Antibiotics in Laboratory Medicine 2nd ed., Baltimore, MD , (1986), 694-696 | |
| 3. Kadurugamuwa, J., et al., Surface action of gentamicin on Pseudomonas aeruginosa J. Bacteriol. 175, 5798-5805, (1993) |
